Eberechi Eze started on the left wing in Arsenal's win over Nottingham Forest on Sunday, but he struggled and was replaced at half-time.
Madueke came off the bench to score the winner and he has looked bright in his appearances on that flank.
Noni Madueke scoring against Nottingham Forest
Getty
Mikel Arteta has made two changes as his squad is strong enough to rotate slightly without weakening the side.
Jurrien Timber comes in at right-back, as he continues to share the minutes with Ben White.
In midfield, Myles Lewis-Skelly has to wait for his chance over Bruno Guimaraes, while Martin Zubimendi is available again and “will be involved” after a minor hamstring issue.
Kai Havertz has not been at his best since the international break, but is chosen up front despite Viktor Gyokeres, who is yet to score for Arsenal this season, starting the previous Champions League matches this season.
"If he is able to train the next few days he can be available for Everton, which is great news,” Arteta said.
CONFIRMED TEAM NEWS
Arsenal XI: Raya; Timber, Konsa, Gabriel, Calafiori; Guimaraes, Rice; Saka, Odegaard, Madueke; Havertz
Substitutes: Kepa, Meslier, Mosquera, White, Eze, Gyokeres, Merino, Zubimendi, Lewis-Skelly, Dowman
Injured: Saliba, Hincapie, Tzolis
Time and date: 8pm BST on Wednesday, October 21, 2026
How to watch: TNT Sports
Venue: Allianz Arena