Elsewhere in England's line-up, prop Hannah Botterman features after coming on as a replacement in the dramatic win over New Zealand last time out.
With Marlie Packer staying in England as her partner and Red Roses team-mate Rosie Galligan is due to give birth, Abi Burton takes a spot in the back row, while Tatyana Heard's direct running is preferred to Helena Rowland's playmaking ability at inside centre.
Sadia Kabeya, who missed the win over the Black Ferns with a leg injury, is on the bench, alongside Bristol Bears' 20-year-old Demelza Short, who covers second row.
"The first Test in Exeter gave us a valuable opportunity to test our game under pressure and identify where we can improve," England head coach John Mitchell said.
"Playing in Toronto presents a different environment and challenge, and we're excited by the opportunity to express our game, improve our performance and continue to grow as the Red Roses."
England's last loss came in the Rugby World Cup final against New Zealand in November 2022.
England: Kildunne; Breach, Jones, Heard, Moloney-MacDonald; Harrison, L Packer; Botterman, Cokayne, Bern, Talling, Ives Campion, Burton, Matthews, Feaunati.
Replacements: Field, Carson, Muir, Short, Kabeya, Hunt, Rowland, Sing.