The 71-year-old underwent a 90 minute surgery on Tuesday at Rome's Gemelli Hospital and was subsequently diagnosed with lung adenocarcinoma.
Pope Leo XIV has been diagnosed with lung cancer but had successful surgery to remove a lower lobe of his right lung, the Vatican has said in a medical bulletin.
The 71-year-old underwent a 90 minute surgery on Tuesday at Rome's Gemelli Hospital and was subsequently diagnosed with lung adenocarcinoma.
"The operation was successful and there were no complications," the Vatican said. "After the operation, the Pope awoke normally and returned after a brief period of observation to his room," it added.
The lump was first detected during what the Vatican has described as "routine checks". The Pope is expected to remain in hospital for about a week.
Earlier, large crowds waited for hours outside the hospital for the Pope.
They cheered greetings and well wishes as he passed, while he waved and smiled back through the lowered back window of his car.
He was then met by staff on the hospital steps. "I'm sorry," one of them commiserated, to which the Pope gave a smile and a shrug. "We're here for you," he was assured.
In its statement, the Vatican said the whole lower lobe of the Pope's right lung was removed "to ensure the procedure was radical".
A Vatican source told Agence France-Presse news agency further tests were being carried out to see if there was any sign the cancer had spread.
It was Leo XIV himself who on Sunday announced news of his operation to the world, speaking from the balcony in St Peter's Square after delivering the traditional Angelus blessing.
He said the nodule, or growth, on his lung was "contained" and had been found "at a very early stage", but that doctors had advised him to have it removed.
"Am I worried? Yes, because I certainly wasn't expecting anything like this," Vatican Secretary of State Cardinal Parolin told journalists on Tuesday.
He agreed that the news was like a "bolt from the blue", but said the cardinals had been struck by the Pope's "serenity" and were confident in his recovery.
Outside Gemelli Hospital, which has treated several popes and is home to a large statue of John Paul II, a few Catholics lingered after the pontiff was admitted.
Carla had come specially, wanting to be close.
"He seems calm, so we are calm too - even though illness is always unpleasant," she told the BBC. "We will wait here and pray."
"I was in St Peter's Square when he made the announcement, and I felt really awful," said Elsa, who was also present. "I was really taken aback," she said, explaining that when Pope Leo was elected she had thought he was a younger, healthier pontiff.
"It turns out he's vulnerable too," she added.
