Defeat at the Camp Nou would not necessarily be terminal for Los Blancos and their title hopes, though clawing back a nine-point deficit against this Barcelona team suggests they cannot afford to lose.
Tonight marks Jose Mourinho’s first taste of an El Clasico in 13 long years, having returned to the Spanish capital in the summer, and just a second-ever meeting with Hansi Flick.
Where to watch Barcelona vs Real Madrid
TV channel: In the UK, the game will be televised live on Premier Sports. Coverage starts on Premier Sports 1 at 7.30pm GMT ahead of a 8pm kick-off.
Live stream: Premier Sports subscribers can also catch the contest live online via the Premier Sports app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.