Donyell Malen will lead the Roma attack in an away game at Napoli, but Paulo Dybala remains injured, and Massimiliano Allegri will look to Rasmus Hojlund.
It kicks off at 18:00 CET [17:00 BST] at the Stadio Maradona.
The home side must cope without Alisson Santos and David Neres, as well as Costantino Favasuli and Alessandro Buongiorno.
Chelsea loanee Benoit Badiashile is the favourite over Amir Rrahmani at centre-back, as the latter is not fully fit and needs rest. Zambo Anguissa is favourite over Stanislav Lobotka in a midfield department completed by Kevin De Bruyne and Scott McTominay.
Roma, meanwhile, have travelled to Naples without Paulo Dybala, Manu Koné, Mile Svilar and Lorenzo Pellegrini.
According to Sky Sport Italia, Dybala is close to returning to action as Roma hope the Argentine will be available for the upcoming mid-week round against Cagliari.
There’s doubt over Nahuel Molina and Emanuele Lulli at right back, and over Rodrigo Mora and Bryan Cristante in the attacking midfield slot.
Napoli vs. Roma – where to watch on TV
The match will be broadcast live on TNT Sports 4, DAZN and HBO Max and on Paramount+ in the USA. Football Italia will provide live updates via a live blog.
Napoli vs. Roma – probable line-ups
Napoli (4-3-3): Milinkovic-Savic; Di Lorenzo, Badiashile, Marín, Olivera; Anguissa, De Bruyne, McTominay; Politano, Hojlund, Lang.
Roma (3-4-2-1): Gollini, Mancini, Ndicka, Hermoso; Lulli, Pisilli, de Roon, Wesley; Soulé, Cristante; Malen.