Como look to Martin Baturina, Nico Paz and Tasos Douvikas for a home Champions League game against Manchester United.
It kicks off at 18:45 CET [17:45 BST] at the Stadio Sinigaglia in Como.
You can follow the build-up and live action on the Football Italia Liveblog.
The home side are without the injured Trevoh Chalobah, Moise Kean, Jesus Rodriguez and Assane Diao. As Jesus Rodriguez will remain out of action for more than two months with a muscle injury, Como have been allowed to change their Champions League squad list, replacing the Spaniard with Maxence Caqueret.
The Frenchman is available for today’s game but will start on the bench, as Fabregas has picked Lucas Da Cunha, Nico Paz and Baturina behind the sole striker, Douvikas. Luis Milla and Maximo Perrone are the preferred midfielders.
Serie A fans will see some familiar faces in the Manchester United starting XI, with Diogo Dalot and Bruno Fernandes featuring.
Michael Carrick, however, must cope without the suspended Leny Yord and the injured Benjamin Sesko. Marcus Rashford, Patrick Dorgu, Kobbie Mainoo, Lisandro Martinez, Luke Shaw, Ayden Heaven and Manuel Ugarte.
Both Como and Manchester United have one win and one loss in their opening two Champions League games this season.
Como vs. Manchester United – official Champions League line-ups
Como (4-2-3-1): Butez; Couto, Ramon, Kempf, Valle; Milla, Perrone; Da Cunha, Paz, Baturina; Douvikas.
Man United (4-2-3-1): Lammens; Mazraoui, De Ligt, Maguire, Dalot; Tielemans, Santos; B. Fernandes, Mount, Cunha; Mbeumo.