Scott McTominay and Billy Gilmour are expected to start for Napoli in an away Champions League match against Villarreal.
It kicks off at 21:00 CET [20:00 BST] at the Estadio de la Cerámica in Vila-real, Spain.
The Partenopei still lack depth in attack, with Alisson Santos and Antonio Vergara injured, and the same is true in central defence, with Alessandro Buongiorno out.
Multiple Italian sources, including Sky Sport Italia, claim that Napoli coach Massimiliano Allegri will stick to a three-man defence after beating Frosinone 3-0 in Serie A this past Saturday.
Scotland internationals Gilmour and McTominay are expected to start in central midfield. McTominay will make his first Napoli start after undergoing a minor heart procedure in September. He already returned to action last weekend, coming off the bench as a substitute against Frosinone.
Brazilian striker Giovane has been reintroduced to the Napoli UEFA list following an injury to Costantino Favasuli and challenges Noa Lang for a starting spot in attack to partner Rasmus Hojlund.
Villarreal vs. Napoli – where to watch on TV
The match is available on TNT Sports 6 and HBO Max in the UK and Ireland and on Paramount+ in the USA. Football Italia will provide live updates for this match and Inter-Club Brugge via a live blog.
Villarreal vs. Napoli – probable line-ups
Villarreal (4-4-2): Gulacsi; Mourino, Foyth, Renato Veiga, Carlos Romero; Ilias, Pape Gueye, Saliba, Moleiro; Gerard, Mikautadze.
Napoli (3-4-2-1): Milinkovic-Savic; Rafa Marin, Rrahmani, Badiashile; Di Lorenzo, Gilmour, McTominay, Spinazzola; Giovane, De Bruyne; Hojlund.