Ivan Provedel makes his Inter debut in a Serie A match against Fiorentina, with Francesco Pio Esposito and Marcus Thuram starting up front, while the Tuscans look to Mateo Pellegrino.
It kicks off at 12:30 CET [11:30 GMT] at the Stadio Meazza in San Siro, Milan.
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The Nerazzurri need a win to catch Lazio at the top of the Serie A table after the Biancocelesti beat Parma 2-1 on Saturday night.
Inter are without the injured John Stones, Curtis Jones, Lautaro Martinez, Benjamin Pavard and Luis Henrique, while Fiorentina have travelled to Milan without Fabiano Parisi, Arthur Atta and Luca Ranieri.
Cristian Chivu picks Pio Esposito and Thuram up front, while Andy Diouf returns to the starting XI at right midfield, so Djed Spence starts on the bench.
Ivan Provedel makes his debut in goal, replacing Josep Martinez. Federico Dimarco rests, so Carlos Augusto starts on the left wing. The Brazilian has scored four goals and provided two in eight games across all competitions this season.
Argentine centre-forward Pellegrino starts up front for the Tuscans, while Marco Brescianini joins Cher Ndour and Nicolò Fagioli in central midfield.
Inter remain unbeaten in Serie A this season, with six wins and one draw, and have earned four points so far, though they have lost three of their last five games.
Inter vs. Fiorentina – official line-ups
Inter (3-5-2): Provedel; Bisseck, Akanji, Bastoni; Diouf, Barella, Calhanoglu, Mkhitaryan, Carlos Augusto; Thuram, Esposito.
Fiorentina (4-3-3): De Gea; Jimenez, Dragusin, Pongracic, Valdepenas; Ndour, Fagioli, Brescianini; Mastantuono, Pellegrino, Njie.