The game which will take place at the Stadio Giuseppe Sinigaglia, following approval from UEFA, will be an historic one as it is the first time Man United have faced Como in a competitive fixture.
However, Michael Carrick may have been handed a selection dilemma as TEN senior players could miss the trip to Italy.
Kobbie Mainoo, Luke Shaw, Ayden Heaven, Martinez and Rashford were all absent from Tuesday morning’s training session at Carrington, sparking fears they will not be named in the travelling squad later.
Rashford, meanwhile, was a unused substitute at Elland Road and Carrick has confirmed the England international has been carrying a knock recently.
“Marcus has been carrying a little bit of something so we’re managing him to a point,” the Man United head coach confirmed.
Doubtful: Marcus Rashford missed Tuesday morning’s training session
PA
As expected, long-term absentees Benjamin Sesko, Patrick Dorgu and Manuel Ugarte were all absent from the training session, as was third-choice goalkeeper Tom Heaton.
Leny Yoro is guaranteed to sit out against Como as he serves a suspension after being sent-off in the Spanish capital.
Carrick will provide a full team news update at his news conference on Tuesday evening at the Stadio Giuseppe Sinigaglia, where he will be joined by a Man United player.