Juventus start Randal Kolo Muani and Nick Woltemade together for the first time as they try to keep the perfect Europa League start going against Rennes.
It kicks off at the Allianz Juventus Stadium in Turin at 17.45 UK time (18.45 CEST).
Juve have been in crisis in Serie A and are fresh off a disastrous 3-0 home defeat to Lazio, yet sit top of the Europa League table after wins over NEC Nijmegen and Celta Vigo.
It remains to be seen which version of the Old Lady will turn up this evening, but Luciano Spalletti transforms the tactics by using Woltemade and Kolo Muani together for the first time, something both strikers have been publicly appealing for.
This looks to be a 3-4-1-2 formation with Weston McKennie in a free role behind the strikers, Andrea Cambiaso and Zeki Celik pushed into more advanced positions.
Francisco Conceicao joins the long list of absentees after a shoulder injury, with Kenan Yildiz, Manuel Locatelli, Jeff Ekhator and Kamil Grabara, while Edon Zhegrova is not on the UEFA list.
Rennes sit sixth in Ligue 1 and have four points from two Europa League games, earning a 0-0 draw away to Sturm Graz and beating OFI Crete 2-1 with a late comeback.
They too suffered defeat domestically at the weekend, a 4-3 thriller away to Paris FC decided deep into stoppages.
Esteban Lepaul scored a hat-trick of penalties in that match, but he also sustained an ankle injury that forced them to end the game with 10 men, so has not made the trip to Turin.
Coach Franck Haise is therefore tempted to change to a three-man defence, which is really more like five at the back, after some poor away results.
There are some familiar faces, as former Lazio striker Boulaye Dia starts upfront with Mousa Al-Taamari.
Midfielder Valentin Rongier has been linked with Serie A moves in the past, including to Juventus last year.
Juventus vs. Rennes line-ups
Juventus: Vicario; Gatti, Bremer, Kelly; Cambiaso, Douglas Luiz, Koopmeiners, Celik; McKennie; Woltemade, Kolo Muani
Juventus bench: Pinsoglio, Neto, Boga, Kalulu, Alajbegovic, Lucumi, Sarr, Nico Gonzalez, Cabal, Merola
Rennes: Samba; Ait Boudlal, Cresswell, Rouault; Reynolds, Camara, Rongier, Thomasson, Nagida; Dia, Al-Taamari
Rennes bench: Lemaitre, Belazzoug, Goncalo Oliveira, Cisse, Blas, Mayenda, Szymanski, Merlin, Do Marcolino, Nordin, Soumaré, Frankowski
Ref: Krogh (DEN)
