Panthers outside linebacker Jaelan Phillips aggravated his hamstring in the first quarter.
The team lists his return as questionable.
Thomas Incoom replaced Phillips but was hurt while covering a punt on a blindside block by Feleipe Franks. He limped off the field.
Incoom is questionable to return with a calf injury.
The Eagles have ruled out outside linebacker Nolan Smith with a concussion. He appeared to be knocked out on a chip block by Chuba Hubbard in the second quarter.
The Eagles have only Jonathan Greenard, Arnold Ebiketien and Keyshawn James-Newby at the position.
The Panthers lead 3-0 on Ryan Fitzgerald's 47-yard field goal.