Maximilian Senft makes four changes from the defeat to St. Pauli. Sebastian Jung, Kevin Wiethaup, Santeri Väänänen and Noel Eichinger replace Deniz Ofli, Danyal Zor, Rafael Pinto Pedrosa and Louey Ben Farhat.
Florian Kohfeldt makes two changes after the 3-1 victory over Cottbus as Hiroki Akiyama and Lance Duijvestijn come in for Nicolas Verkooijen and Noah Weißhaupt.
Confirmed Karlsruher SC vs. SV Darmstadt 98 lineups
Karlsruher SC (3-5-2): Bernat; Kobald, Franke, Trémoulet; Jung, Wiethaup, Wanitzek, Väänänen, Bergh; Fukuda, Eichinger
SV Darmstadt 98 (4-4-2): Schuhen; Mikelbrencis, Pfeiffer, Vukotić, Petretta; Duijvestijn, Akiyama, Klefisch, Richter; Smit, Lee