The final game of Week 6 will be a Monday Night Football matchup featuring the Washington Commanders (1-3-1) on the road against the San Francisco 49ers (5-0).
The 49ers lead the all-time series between these teams, 20-11-1, and have won three of their four most-recent meetings. They last faced off back in 2023, when the 49ers had an easy day on the East Coast against the Commanders, winning 27-10.
Here’s everything you need to know about tonight’s game.
Washington Commanders vs. San Francisco 49ers
TV Schedule
Game time: 8:15 PM EST
Channel: ESPN
Date: Monday, October 18, 2026
Location: Levi’s Superdome | Santa Clara, CA
Announcers: Joe Buck, Troy Aiman, Lisa Salters (field reporter) and Laura Rutledge (field reporter)
Online Streaming
Odds via FanDuel
Oddscourtesy of FanDuel
Washington Commanders: +7.5 (+330)
San Francisco 49ers: -7.5 (-420)
Over/under: 51.5 points
SB Nation Blogs
Commanders: www.HogsHaven.com
49ers: www.NinersNation.com
Open thread: Discuss Monday night’s game in the comments below.