The Bundesliga champions will miss Michael Olise, who is suspended on the continent after his red card against Viking last time out, while manager Vincent Kompany will also not be on the touchline having picked up a viral infection.
Olise, the former Crystal Palace winger, was seen training with his team-mates ahead of the league phase encounter, but he is not eligible to play due to his ban.
There is good news, however, in the Bayern camp with Joshua Kimmich looking like he will be available to face the Gunners.
Suspended: Michael Olise
PA
Another name that will not play against the Premier League champions is Jamal Musiala, who remains sidelined with a thigh tear that he suffered on international duty last month.
He is thought to be out for another week or so, totalling his time out at just about a month.
Otherwise, Manuel Neuer could return between the sticks after being spotted in training.
The veteran goalkeeper has suffered with a foot problem in recent weeks, which has seen Jonas Urbig given a chance in net, but the 40-year-old could make a comeback here.
Ahead of him, Konrad Laimer should get the nod at right-back, with Alphonso Davies on the opposite side ahead of Nathaniel Brown.
Dayot Upamecano and Jonathan Tah are likely to be the central defensive duo, with Kimmich partnered by Aleksandar Pavlovic in the engine room.
Ismael Saibari operated as the No10 last time out, while Lennart Karl could come in to replace the suspended Olise on the right flank.
Luis Diaz and Harry Kane will complete the attacking quartet.
Predicted Bayern XI (4-2-3-1): Neuer; Laimer, Upamecano, Tah, Davies; Kimmich, Pavlovic; Karl, Saibari, Diaz; Kane
Injured: Musiala
Suspended: Olise
Date and time: 8pm BST on Wednesday, October 21, 2026
Venue: Allianz Arena
How to watch: TNT Sports